LaVine scored 51 points as he knocked down 19 of 33 field-goal attempts and 6 of 8 free throws.
Jalen Duren supplied 23 points, 15 rebounds and five assists as Detroit snapped its 15-game losing streak against the Bulls.
Joel Embiid also scored 34 points to go with nine rebounds, eight assists and two blocked shots.
Anthony Edwards added 19 points and seven assists and Gobert contributed 14 points and 14 rebounds.
Grayson Allen scored 14 of his 17 points in the third quarter for Phoenix, which has won two of its first three games.
Persons:
Cade Cunningham, Rick Osentoski, Zach LaVine, LaVine, DeMar DeRozan, Nikola Vucevic, Jalen Duren, Alec Burks, DeRozan, Tyrese Maxey, Nick Nurse's, Joel Embiid, Nurse, Scottie Barnes, Gary Trent Jr, Gradey Dick, Naz Reid, Reid, Anthony Edwards, Gobert, Jimmy Butler, Jimmy, Caleb Martin, Kevin Love, Herro, Bam Adebayo, Aaron Nesmith, Tyrese Haliburton, Myles Turner, outlasting Donovan Mitchell, Turner, Mitchell, Evan Mobley, Caris, Mobley dunked, Jordan Poole, Corey Kispert, Kyle Kuzma, Kuzma, Daniel Gafford, Desmond Bane, Brandon Ingram, Zion Williamson, RJ Barrett, Jalen Brunson, Julius Randle, Mitchell Robinson, Josh Hart, Kevin Durant, Phoenix trounce, Eric Gordon, Grayson Allen, Lauri Markkanen
Organizations:
Detroit Pistons, Jalen, Chicago Bulls, Little Caesars Arena, Detroit, Bulls, LaVine, Pistons, 76ers, Raptors, Philadelphia, NBA, Timberwolves, Miami, Pacers, Cavaliers, Indiana, Haliburton, Wizards, Grizzlies, Washington, The Grizzlies, Knicks, New Orleans, New York, Atlanta, Pelicans, Suns, Jazz, Phoenix, Utah, Thomson
Locations:
Detroit , Michigan, USA, Jalen Duren, Toronto, Minnesota, Minneapolis, Cleveland, Cleveland's, Haliburton, Memphis, Washington, New, Utah